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Prolotherapy is also known as "proliferation therapy" or "regenerative injection therapy" or "proliferative injection therapy".

What is Prolotherapy?

Prolotherapy involves injecting an otherwise non-pharmacological and non-active irritant solution into the body, generally in the region of tendons or ligaments for the purpose of strengthening weakened connective tissue and alleviating musculoskeletal pain.

What substances are used in Prolotherapy?

The substances used in prolotherapy injections are designed to promote growth of normal tissues around the area being treated. Most commonly, hyperosmolar dextrose (a sugar) is the solution used, glycerine, lidocaine (a commonly used local anesthetic), phenol and sodium morrhuate, a derivative of cod liver oil extract are other commonly used agents. The injection is administered at joints or at tendons where they connect to bone. Prolotherapy stimulates tissues to regenerate and populate spaces left following damage by gently irritating the area to trigger an inflammatory process that speeds up healing.

How many sessions of Prolotherapy are generally required?

Prolotherapy treatment sessions are generally given every two to six weeks for several months in a series ranging from 3 to 6 or more treatments. Many patients receive treatment at less frequent intervals until treatments are rarely required, if at all.

Which conditions can be benefited by Prolotherapy?

The following conditions can be benefited by Prolotherapy:
* Low back pain
* Osteoarthritis of the Knee, hip and small joints
* Neck strain
* Pain from whiplash injury
* Shoulder dislocation
* Rotator Cuff injuries
* Costochondritis
* Fibromyalgia
* Achilles tendinopathy
* Sacroiliac joint dysfunction
* Lateral epicondylitis
* Plantar fasciitis
* Recurring ankle sprains
* Headaches

What are the side effects of Prolotherapy?

Patients receiving prolotherapy injections have reported generally mild side effects including: mild pain and irritation at the injection site (often within 72 hours of the injection), numbness at the injection site, or mild bleeding. Pain from prolotherapy injections is temporary and is often treated with acetaminophen or in rare cases opioid medications.

Theoretical adverse events of prolotherapy injection include lightheadedness, allergic reactions to the agent used, infection, or nerve damage. However, allergic reactions to sodium morrhuate are rare. Rare cases of back pain, neck pain, spinal cord irritation, pneumothorax, and disc injury have been reported at a rate comparable to that of other spinal injection procedures.

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